Gareth Hawkes

Apr 26, 2024 | genomemedicine.biomedcentral.com | Robin Beaumont |Gareth Hawkes |Adam C Gunning |Caroline Wright

Variants from exome sequencing (ES) data within the UK Biobank were called centrally by the UKB team using graphTyper [19]. We used the Ensembl VEP v104 [20] with the LOFTEE plugin [15] to annotate the variants with their predicted functional consequences. We excluded variants which were flagged for removal by UKB due to low depth based on 90% of calls having depth < 10.

Nov 20, 2023 | biorxiv.org | Gareth Hawkes |Robin Beaumont |Zilin Li |Ravi Mandla

AbstractThe role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100 individuals from three datasets: UK Biobank (N=200,003), TOPMed (N=87,652) and All of Us (N=45,445).

Oct 12, 2023 | medrxiv.org | Robin Beaumont |Gareth Hawkes |Adam C Gunning |Caroline Wright

The authors have declared no competing interest. This work was supported by the Medical Research Council [MR/T00200X/1]I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Jun 22, 2023 | nature.com | Saleh Shekari |Stasa Stankovic |Eugene J. Gardner |Gareth Hawkes |Katherine A. Kentistou |Robin Beaumont | +6 more

Author notesThese authors contributed equally: Saleh Shekari, Stasa Stankovic, John R. B. Perry, Anna Murray. Authors and AffiliationsDepartment of Clinical and Biomedical Sciences, University of Exeter, Exeter, UKSaleh Shekari, Gareth Hawkes, Robin N. Beaumont, Andrew R. Wood, Caroline F. Wright, Michael N. Weedon, Katherine S. Ruth & Anna MurraySchool of Public Health, Faculty of Medicine, University of Queensland, Brisbane, Queensland, AustraliaSaleh Shekari & Gita D.