Ravi Mandla

Jul 15, 2024 | medrxiv.org | Ravi Mandla |Xianyong Yin |Ozvan Bocher |Kimberly Lorenz

J.B.M is an academic associate for Quest Diagnostics Inc. Endocrine R&D. MIMcC is now an employee of Genentech and a holder of Roche stock. A.H. is supported by the American Diabetes Association grant #11-23-PDF-35. O.B. has received funding from the European Unions Horizon 2020 research and innovation programme under Grant Agreement No 101017802 (OPTOMICS). A.P. is supported by the Wiener-Anspach Foundation, and the Fonds National de la Recherche Scientifique (FNRS).

Apr 26, 2024 | genomemedicine.biomedcentral.com | Ravi Mandla |Philip Schroeder |Bianca Porneala |Jose C. Florez |James B. Meigs |Josep M. Mercader | +1 more

We sought to evaluate the longitudinal predictive performance of T2D PGS for incident T2D by creating simulated scenarios that varied in depth of clinical data availability at the time of each patient’s initial clinical encounter in the MGH PCP network. We extracted two decades of clinical data for 284,602 patients who had received primary care through the network from an EHR repository including outpatient, emergency department, and inpatient visits.

Nov 20, 2023 | biorxiv.org | Gareth Hawkes |Robin Beaumont |Zilin Li |Ravi Mandla

AbstractThe role of rare non-coding variation in complex human phenotypes is still largely unknown. To elucidate the impact of rare variants in regulatory elements, we performed a whole-genome sequencing association analysis for height using 333,100 individuals from three datasets: UK Biobank (N=200,003), TOPMed (N=87,652) and All of Us (N=45,445).