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Nov 5, 2024 | 00399-1&sz=64)
cell.com | Gabriel S.S. Tofani |Sarah-Jane Leigh |Cassandra E. Gheorghe |Thomaz F.S. Bastiaanssen |Lars Wilmes |Paromita Sen | +2 more
Keywords circadian rhythms gut microbiota stress gut-brain axis glucocorticoid HPA axis Introduction The stress and circadian systems are intertwined, being an evolutionary conserved adaptation that allows the organism to respond to changes in the environment.1 Although the stress response is characterized as a rapid adaptive process to actual or perceived danger,2 the circadian rhythm is an endogenous process that anticipates predictable environmental cues.3 Although these two systems have...
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Sep 10, 2024 | 00222-3&sz=64)
cell.com | Lily Keane |APC Microbiome Ireland |John Cryan |Jack Gleeson
Keywordsmicrobiomegut–brain axisgliomatumour microenvironmentmicrobial metabolitesThe cancer microbiomeThe human microbiota (see Glossary) is a complex ecosystem that symbiotically associates with barrier tissues found in the body [1]. The gut microbiome can interact and modulate host responses, especially the immune system [2], and the human gut microbiota consists of approximately 1000 species of bacteria as well as thousands of viruses and a less diverse plethora of archaea and fungi [3–5].
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Apr 23, 2024 | 
nature.com | Sarah Nicolas |Sebastian Dohm-Hansen |John Cryan
AbstractLifestyle factors, especially exercise, impact the manifestation and progression of psychiatric and neurodegenerative disorders such as depression and Alzheimer’s disease, mediated by changes in hippocampal neuroplasticity. The beneficial effects of exercise may be due to its promotion of adult hippocampal neurogenesis (AHN).
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Apr 9, 2024 | 
enviromicro-journals.onlinelibrary.wiley.com | Sarah Nicolas |Gerard Clarke |John Cryan |Leonie Lang
INTRODUCTION With increasing longevity and declining fertility our global population is becoming disproportionality aged. Ageing is associated with an increased incidence of Alzheimer's disease (AD), which is now recognised as one of the most significant health challenges globally with important socio-economic dimensions (Alzheimer's disease facts and figures, 2022).
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Apr 4, 2024 | 
nature.com | Maria R. Aburto |John Cryan
Correction to: Nature Reviews Gastroenterology & Hepatology https://doi.org/10.1038/s41575-023-00890-0, published online 14 February 2024. In the version of the article initially published, in Fig. 1c, the “Gut epithelial barrier” was mislabelled as the “Blood–CSF barrier”. This has now been amended in the HTML and PDF versions of the article.
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Mar 13, 2024 | 
nature.com | John Cryan
With sadness, we mourn the passing of Prof. Brian E. Leonard, Emeritus Professor of Pharmacology at the University of Galway, Galway Ireland on December 27th, 2023 at the age of 87. Prof. Leonard was a Fellow Emeritus and was accepted into ACNP membership in 1983. Over a long and distinguished career, he has left an indelible mark on psychopharmacology research and teaching, most notably in the areas of depression and brain-immune interactions and in training generations across the globe.
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Jan 5, 2024 | 
cambridge.org | Gregers Wegener |Andrew Harkin |John Cryan
With profound respect and a deep sense of loss, we announce the passing of Professor Brian Leonard, Emeritus Professor, University of Galway, Ireland, a distinguished luminary in the field of Psychopharmacology. Brian leaves a long legacy that will persist through his innovative discoveries, especially in the fields of depression and immune–brain interactions and the many trainees who came through his Galway lab.
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Sep 12, 2023 | 
nature.com | John Cryan
CORRESPONDENCE 12 September 2023 We agree that global efforts in science, technology and innovation could accelerate achievement of the United Nations Sustainable Development Goals (SDGs) by their deadline of 2030 (Nature 618, 647; 2023). Incentivizing scientists to contribute to these goals could help to boost and concentrate those efforts.
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Apr 21, 2023 | 
biorxiv.org | Sarah-Jane Leigh |Cassandra E. Gheorghe |Gerard Clarke |John Cryan
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Mar 20, 2023 | 
nature.com | Mary Butler |Sabrina Mörkl |John Cryan |Gerard Clarke
AbstractThe microbiome-gut-brain axis plays a role in anxiety, the stress response and social development, and is of growing interest in neuropsychiatric conditions. The gut microbiota shows compositional alterations in a variety of psychiatric disorders including depression, generalised anxiety disorder (GAD), autism spectrum disorder (ASD) and schizophrenia but studies investigating the gut microbiome in social anxiety disorder (SAD) are very limited.
