Grant Kinsler

Dec 5, 2024 | journals.plos.org | Grant Kinsler |Yuping Li |Gavin Sherlock

Loading metrics Open Access Peer-reviewedResearch Article Citation: Kinsler G, Li Y, Sherlock G, Petrov DA (2024) A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation. PLoS Biol 22(12): e3002848. https://doi.org/10.1371/journal.pbio.3002848Academic Editor: J. Arjan G. M.

Apr 18, 2024 | biorxiv.org | Grant Kinsler |Yuping Li |Gavin Sherlock |Dmitri A. Petrov

AbstractEvolution by natural selection is expected to be a slow and gradual process. In particular, the mutations that drive evolution are predicted to be small and modular, incrementally improving a small number of traits. However, adaptive mutations identified early in microbial evolution experiments, cancer, and other systems often provide substantial fitness gains and pleiotropically improve multiple traits at once.