Dmitri A. Petrov

Apr 18, 2024 | biorxiv.org | Grant Kinsler |Yuping Li |Gavin Sherlock |Dmitri A. Petrov

AbstractEvolution by natural selection is expected to be a slow and gradual process. In particular, the mutations that drive evolution are predicted to be small and modular, incrementally improving a small number of traits. However, adaptive mutations identified early in microbial evolution experiments, cancer, and other systems often provide substantial fitness gains and pleiotropically improve multiple traits at once.

Mar 15, 2024 | journals.plos.org | Manuel Razo-Mejia |Madhav Mani |Dmitri A. Petrov |Chan Zuckerberg Biohub

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Razo-Mejia M, Mani M, Petrov D (2024) Bayesian inference of relative fitness on high-throughput pooled competition assays. PLoS Comput Biol 20(3): e1011937.

Oct 18, 2023 | biorxiv.org | Madhav Mani |Dmitri A. Petrov |Manuel Razo-Mejia

AbstractThe tracking of lineage frequencies via DNA barcode sequencing enables the quantification of microbial fitness. However, experimental noise coming from biotic and abiotic sources complicates the computation of a reliable inference. We present a Bayesian pipeline to infer relative microbial fitness from high-throughput lineage tracking assays. Our model accounts for multiple sources of noise and propagates uncertainties throughout all parameters in a systematic way.