Yuping Li

Dec 5, 2024 | journals.plos.org | Grant Kinsler |Yuping Li |Gavin Sherlock

Loading metrics Open Access Peer-reviewedResearch Article Citation: Kinsler G, Li Y, Sherlock G, Petrov DA (2024) A high-resolution two-step evolution experiment in yeast reveals a shift from pleiotropic to modular adaptation. PLoS Biol 22(12): e3002848. https://doi.org/10.1371/journal.pbio.3002848Academic Editor: J. Arjan G. M.

Oct 23, 2024 | onlinelibrary.wiley.com | Wenyan Ji |Ming Liu |Yuping Li |Lulu Liu

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202405113-sup-0001-SuppMat.docx4.1 MB Supporting Information References 1, , , , Chem. Eng. J. 2021, 409, 127376. 2, , , , Water Res. 2022, 216, 118299. 3, , , , , , AIChE J. 2023, 69, e18204. 4, , Chem. Rev. 2010, 110, 2448. 5, , , , Environ. Sci. Technol. 2022, 56, 2656. 6, , , J. Environ. Manage. 2004, 73, 267. 7, , , , , Sep. Purif. Technol. 2022, 285, 120228.

Aug 26, 2024 | biorxiv.org | Daphne Chen |Leah Roe |Yuping Li |Adair Borges

AbstractPhage-encoded anti-CRISPR (Acr) proteins inhibit CRISPR-Cas systems to allow phage replication and lysogeny maintenance. Most of the Acrs characterized to date are stable stoichiometric inhibitors, and while enzymatic Acrs have been characterized biochemically, little is known about their potency, specificity, and reversibility. Here, we examine AcrIF11, a widespread phage and plasmid-encoded ADP-ribosyltransferase (ART) that inhibits the Type I-F CRISPR-Cas system.

Apr 18, 2024 | biorxiv.org | Grant Kinsler |Yuping Li |Gavin Sherlock |Dmitri A. Petrov

AbstractEvolution by natural selection is expected to be a slow and gradual process. In particular, the mutations that drive evolution are predicted to be small and modular, incrementally improving a small number of traits. However, adaptive mutations identified early in microbial evolution experiments, cancer, and other systems often provide substantial fitness gains and pleiotropically improve multiple traits at once.

Dec 9, 2023 | cell.com | Qianqian Li |Susan Duncan |Yuping Li

HighlightsEpigenetic mechanisms exert control over secondary metabolite production by modulating chromatin conformation to govern transcriptional activity. Arabidopsis (Arabidopsis thaliana) flowering time gene regulation provides a valuable model for studying transcriptional and epigenetic regulation at the chromatin level.