Guohua Wang

Dec 13, 2024 | mdpi.com | Guohua Wang

1. IntroductionAs a gathering place of resources (including more employment opportunities, better medical and educational environment, and more convenient living and transportation conditions), cities attract a large population to settle down. Urban space is gathering more and more resources and population in the process of urbanization, from the spatial expansion in the early stage to the shrewd contraction later, making the living environment increasingly crowded [1].

Nov 19, 2023 | nature.com | Guohua Wang

AbstractHypobaric hypoxia (HH) exposure affects appetite and serum iron levels in both humans and animals. Thus, whether appetite-regulating ghrelin is involved in iron regulation under HH needs to be elucidated. In vivo, C57BL/6J mice were placed in a hypobaric chamber to establish a 6000-m-high altitude exposure animal model. In vitro, mouse primary hepatocytes and peritoneal macrophages were exposed to hypoxia (1% O2) to examine the effects of ghrelin on iron-regulating proteins.

Oct 19, 2023 | nature.com | Jiangning Song |Robin B Gasser |Ruedi Aebersold |Guohua Wang

AbstractCell type deconvolution is a computational method for the determination/resolution of cell type proportions from bulk sequencing data, and is frequently used for the analysis of divergent cell types in tumour tissue samples. However, deconvolution technology is still in its infancy for the analysis of cell types using proteomic data due to challenges with repeatability/reproducibility, variable reference standards and the lack of single-cell proteomic reference data.

Jun 25, 2023 | biorxiv.org | Kevin Emmerich |Steven Walker |Guohua Wang |David White

AbstractRetinal Muller glia (MG) can act as stem-like cells to generate new neurons in both zebrafish and mice. In zebrafish, retinal regeneration is innate and robust, resulting in the replacement of lost neurons and restoration of visual function. In mice, exogenous stimulation of MG is required to reveal a dormant and, to date, limited regenerative capacity. Zebrafish studies have been key in revealing factors that promote regenerative responses in the mammalian eye.

Feb 9, 2023 | biorxiv.org | Kevin Emmerich |Steven Walker |Guohua Wang |David White

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.