Haley Dugan

1 month ago | science.org | Varun Arvind |Emanuel J. Novais |Jonathan Oesterle |Daniel Maurer |Mya Vu |Haley Dugan | +5 more

AbstractMonoclonal antibodies (mAbs) targeting the influenza hemagglutinin (HA) can be used as prophylactics or templates for next-generation vaccines. Here, we isolated broad, subtype-neutralizing mAbs from human B cells recognizing the H1 or H3 HA “head” and a mAb engaging the conserved stem. The H1 mAbs bind the lateral patch epitope on HAs from 1933 to 2021 and a prepandemic swine H1N1 virus. We improved neutralization potency using directed evolution toward a contemporary H1 HA.

2 months ago | cell.com | Jenna J Guthmiller |Linda Yu-Ling Lan |Yanbin Fu |Sean Nelson |Carole Henry |Christopher T. Stamper | +9 more