Mya Vu

2 months ago | science.org | Varun Arvind |Emanuel J. Novais |Jonathan Oesterle |Daniel Maurer |Mya Vu |Haley Dugan | +5 more

AbstractMonoclonal antibodies (mAbs) targeting the influenza hemagglutinin (HA) can be used as prophylactics or templates for next-generation vaccines. Here, we isolated broad, subtype-neutralizing mAbs from human B cells recognizing the H1 or H3 HA “head” and a mAb engaging the conserved stem. The H1 mAbs bind the lateral patch epitope on HAs from 1933 to 2021 and a prepandemic swine H1N1 virus. We improved neutralization potency using directed evolution toward a contemporary H1 HA.

Feb 28, 2025 | cell.com | Daniel Maurer |Mya Vu |Aaron Schmidt

Keywordsviral evolutionoriginal antigenic sinviral escapeaffinity maturationantigenic driftimprintingplasmablastsrecalled immunityGet full text accessLog in, subscribe or purchase for full access. References1. Gouma, S. ∙ Anderson, E.M. ∙ Hensley, S.E.Challenges of making effective influenza vaccinesAnnu. Rev. Virol. 2020; 7:495-5122. Bedford, T. ∙ Suchard, M.A. ∙ Lemey, P. ... Integrating influenza antigenic dynamics with molecular evolutioneLife. 2014; 3, e019143.