Jonathan Oesterle

1 month ago | science.org | Varun Arvind |Emanuel J. Novais |Jonathan Oesterle |Daniel Maurer |Mya Vu |Haley Dugan | +5 more

AbstractMonoclonal antibodies (mAbs) targeting the influenza hemagglutinin (HA) can be used as prophylactics or templates for next-generation vaccines. Here, we isolated broad, subtype-neutralizing mAbs from human B cells recognizing the H1 or H3 HA “head” and a mAb engaging the conserved stem. The H1 mAbs bind the lateral patch epitope on HAs from 1933 to 2021 and a prepandemic swine H1N1 virus. We improved neutralization potency using directed evolution toward a contemporary H1 HA.

1 month ago | science.org | Varun Arvind |Emanuel J. Novais |Jonathan Oesterle |Jie Tu |Hangren Li |Xudong Liu | +18 more

AbstractDouble-perovskite films have been extensively studied in multifunctional fields due to their modifiability. Here, a controlled process strategy to induce chemical strain and anomalous Poisson deformation is proposed for perovskite-based films. The chemical negative strain in the local-ordering BiSmFe2O6 double-perovskite films can be regulated by oxygen engineering to cause the effectively tunable bandgap.