Hannah P. Luehmann

Mar 4, 2025 | cell.com | Yuriko Terada |Wenjun Li |Junedh Amrute |Charles Liu |Andrew Koenig |Hannah P. Luehmann | +15 more

KeywordsmacrophagestransplantationheartTREM-1/3CCR2Research topic(s)CP: ImmunologyIntroductionCardiac transplantation remains the ultimate treatment for patients with end-stage heart disease.1 Myocardial ischemia-reperfusion injury (IRI) is a form of sterile inflammation that is of major clinical significance as it adversely impacts both short- and long-term outcomes.

Oct 23, 2024 | nature.com | Junedh Amrute |Tracy M. Yamawaki |Sikander Hayat |Andrea Bredemeyer |In-Hyuk Jung |Andrew Koenig | +9 more

AbstractInflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction1,2. However, the molecular mechanisms driving immune–fibroblast cell communication in human cardiac disease remain unexplored and there are at present no approved treatments that directly target cardiac fibrosis3,4. Here we performed multiomic single-cell gene expression, epitope mapping and chromatin accessibility profiling in 45 healthy donor, acutely infarcted and chronically failing human hearts.