Hanqing Chen

Mar 7, 2025 | molecular-cancer.biomedcentral.com | Xiaowen Xie |Weici Liu |Zhiyuan Yuan |Hanqing Chen |Wenjun Mao

The epigenome exhibits cell-type-specific variations and undergoes dynamic changes in response to environmental factors, regulating gene expression through multiple mechanisms [3]. Multiple factors-induced aberrant DNA methylation and histone modifications play a pivotal role in tumor initiation and progression by modulating the expression of tumor-associated genes and influencing processes such as cell death and metabolism (Fig. 2).

Dec 20, 2024 | cell.com | Yang Chen |Hao Qin |Nan Li |Yaohua Wei |Yixuan Lin |Ronghui Deng | +10 more

Keywords autologous tumor vaccines tumor membrane antigens neoadjuvant chemotherapy liposomal doxorubicin Introduction Surgery continues to be the primary treatment modality for the majority of solid tumors; however, the challenges of postoperative tumor recurrence and metastasis persist.1,2 Various strategies have been devised in response to these challenges, including using autologous tumor vaccine.3,4,5 These personalized vaccines leverage patients’ tumor cells as a source of antigens to...