Zhiyuan Yuan

3 weeks ago | nature.com | Shuangsang Fang |Mengyang Xu |Zhiyuan Yuan |Yao Li |Vladimir Kovacevic |Lidong Guo | +10 more

AbstractUnderstanding complex biological systems requires tracing cellular dynamic changes across conditions, time, and space. However, integrating multi-sample data in a unified way to explore cellular heterogeneity remains challenging. Here, we present Stereopy, a flexible framework for modeling and dissecting comparative and spatiotemporal patterns in multi-sample spatial transcriptomics with interactive data visualization.

2 months ago | molecular-cancer.biomedcentral.com | Xiaowen Xie |Weici Liu |Zhiyuan Yuan |Hanqing Chen |Wenjun Mao

The epigenome exhibits cell-type-specific variations and undergoes dynamic changes in response to environmental factors, regulating gene expression through multiple mechanisms [3]. Multiple factors-induced aberrant DNA methylation and histone modifications play a pivotal role in tumor initiation and progression by modulating the expression of tumor-associated genes and influencing processes such as cell death and metabolism (Fig. 2).