Heinrich Heine Düsseldorf

Nov 3, 2024 | jneuroinflammation.biomedcentral.com | Heinrich Heine Düsseldorf

Two independent patient and control cohorts were recruited (cohort I: basic mFC cohort and cohort II: in-depth mFC cohort). In total, 309 patients and 129 controls were included in the study. Basic cohort characteristics are summarized in Table 1 and supplementary tables 2–4.

Oct 10, 2024 | genomebiology.biomedcentral.com | Heinrich Heine Düsseldorf |Freie Universität Berlin

While all reads can be used to cluster unitigs by chromosome, only a subset of reads convey haplotype information and are useful for phasing. Accordingly, reads are aligned to the assembly twice: once with bwa mem in paired-end mode [63], to derive the alignments used for clustering and orientation correction, and once with bwa fastmap [63] to identify the phase-informative reads.

Sep 28, 2024 | link.springer.com | Heinrich Heine Düsseldorf

In the age of precision medicine, which is very much driven by successes in the field of mammalian genetics and genomics, the inclusion of digital approaches from brain research offers new opportunities to the field. Data integration, AI-based analysis as well as modeling and simulation from the molecular level to the level of whole organs or organisms create new impact on the understanding of many human diseases (Amunts et al. 2024).

Jul 12, 2024 | journals.plos.org | Mani Erfanian Abdoust |Monja Isabel Froböse |Alfons Schnitzler |Heinrich Heine Düsseldorf

Citation: Erfanian Abdoust M, Froböse MI, Schnitzler A, Schreivogel E, Jocham G (2024) Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans. PLoS Biol 22(7): e3002714. https://doi.org/10.1371/journal.pbio.3002714Academic Editor: Raphael Samuel Matthew Kaplan, Universitat Jaume 1, SPAINReceived: December 14, 2023; Accepted: June 14, 2024; Published: July 12, 2024Copyright: © 2024 Erfanian Abdoust et al.

Jun 12, 2024 | link.springer.com | Heinrich Heine Düsseldorf |Humboldt-Universität zu Berlin

AbstractFatigue is commonly associated with myasthenia gravis (MG), but factors contributing to fatigue development in MG are incompletely understood. This nationwide cross-sectional registry study included 1464 patients diagnosed with autoimmune MG, recruited between February 2019 and April 2023. Frequency and severity of fatigue was assessed at study inclusion using the patient-reported Chalder Fatigue Questionnaire (CFQ). Frequency of fatigue was 59%.