Partner Düsseldorf

Apr 12, 2024 | diabetesjournals.org | Partner Düsseldorf

The RabGTPase-activating protein (RabGAP) TBC1D4 (=AS160) represents a key component in the regulation of glucose transport into skeletal muscle and white adipose tissue (WAT) and is therefore crucial during the development of insulin resistance and type-2 diabetes. Increased daily activity has been shown to be associated with improved postprandial hyperglycemia in allele carriers of a loss-of-function variant in the human TBC1D4 gene.

Dec 4, 2023 | diabetesjournals.org | Heinrich Heine |Partner Düsseldorf |GDS Group

Insulin clearance describes the uptake and degradation of insulin in all insulin-sensitive tissues and thereby contributes to the regulation of circulating insulin concentration. The balance among insulin secretion, sensitivity, and clearance prevents inadequate insulinemia and its metabolic consequences (1). The liver is the main site for insulin clearance and accounts for degrading up to 80% of endogenously secreted and 50% of intravenously infused insulin during the first portal passage (2).

Oct 13, 2023 | academic.oup.com | Partner Düsseldorf |Humboldt-Universität zu Berlin |Christian Herder

Low skeletal muscle mass (SMM) is associated with long-standing diabetes but little is known about SMM in newly diagnosed diabetes. We aimed to identify correlates of SMM in recent-onset diabetes and to compare SMM between novel diabetes subtypes. SMM was normalised to BMI (SMM/BMI) in 842 participants with known diabetes duration of <1 year from the German Diabetes Study (GDS).

Jul 21, 2023 | diabetesjournals.org | Partner Düsseldorf |Heinrich Heine Düsseldorf

Citation Martin Schön, Oana P. Zaharia, Klaus Strassburger, Yuliya Kupriyanova, Kálmán Bódis, Geronimo Heilmann, Alexander Strom, Gidon J. Bönhof, Filippo Michelotti, Iryna Yurchenko, Clara Möser, Maximilian Huttasch, Maria Bombrich, Malte Kelm, Volker Burkart, Vera B. Schrauwen-Hinderling, Robert Wagner, Michael Roden, GDS group; Intramyocellular Triglyceride Content During the Early Course of Type 1 and Type 2 Diabetes Mellitus. Diabetes 2023; db230353.