Monja Isabel Froböse

Jul 12, 2024 | journals.plos.org | Mani Erfanian Abdoust |Monja Isabel Froböse |Alfons Schnitzler |Heinrich Heine Düsseldorf

Citation: Erfanian Abdoust M, Froböse MI, Schnitzler A, Schreivogel E, Jocham G (2024) Dopamine and acetylcholine have distinct roles in delay- and effort-based decision-making in humans. PLoS Biol 22(7): e3002714. https://doi.org/10.1371/journal.pbio.3002714Academic Editor: Raphael Samuel Matthew Kaplan, Universitat Jaume 1, SPAINReceived: December 14, 2023; Accepted: June 14, 2024; Published: July 12, 2024Copyright: © 2024 Erfanian Abdoust et al.

Apr 20, 2024 | biorxiv.org | Mani Erfanian Abdoust |Monja Isabel Froböse |Alfons Schnitzler |Elisabeth Schreivogel

AbstractIn everyday life, we encounter situations that require tradeoffs between potential rewards and associated costs, such as time and (physical) effort. The literature indicates a prominent role for dopamine in discounting of both delay and effort, with mixed findings for delay discounting in humans. Moreover, the reciprocal antagonistic interaction between dopaminergic and cholinergic transmission in the striatum suggests a potential opponent role of acetylcholine in these processes.

Nov 21, 2023 | biorxiv.org | Mani Erfanian Abdoust |Monja Isabel Froböse |Alfons Schnitzler |Elisabeth Schreivogel

AbstractIn everyday life, we encounter situations that require tradeoffs between potential rewards and associated costs, such as time and (physical) effort. The literature indicates a prominent role for dopamine in discounting of both delay and effort, with mixed findings for delay discounting in humans. Moreover, the reciprocal antagonistic interaction between dopaminergic and cholinergic transmission in the striatum suggests a potential opponent role of acetylcholine in these processes.