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1 month ago | 
nature.com | Helen Hope |Pierpaolo Ginefra |Massimo Andreatta |Christine Pich-Bavastro |Jesús Corria Osorio |François Kuonen | +4 more
AbstractChimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show that CAR-T cells generated from aged female mice present a mitochondrial dysfunction derived from nicotinamide adenine dinucleotide (NAD) depletion that leads to poor stem-like properties and limited functionality in vivo.
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Apr 24, 2024 | 
nature.com | Matteo Morotti |Alizée J. Grimm |Helen Hope |Marion Arnaud |David Barras |Catherine Ronet | +14 more
AbstractExpansion of antigen-experienced CD8+ T cells is critical for the success of tumour-infiltrating lymphocyte (TIL)-adoptive cell therapy (ACT) in patients with cancer1. Interleukin-2 (IL-2) acts as a key regulator of CD8+ cytotoxic T lymphocyte functions by promoting expansion and cytotoxic capability2,3.
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Nov 16, 2023 | 
wellandgood.com | Helen Hope
Fitness Fitness Tips Pin It Photo: Getty Images/Igor Alecsander Towards the end of every year, I catch myself lamenting how much my health and fitness routines have slipped in the run-up to the holiday season. Oh well, I’ll just harness that New Year’s resolution energy in January, I think to myself.
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Nov 15, 2023 | 
wellandgood.com | Helen Hope
You’ve been breathing your whole life, so it should be easy to just “take a deep breath”... right? If you’ve ever seriously struggled to match the pace of structured breathwork in a yoga class or guided meditation, you know it’s not always that simple. Alex Artymiak, yoga, meditation, and breath-work teacher based in Santa Monica, California Jasmine Marie, breathworker and founder of Black Girls Breathing Michael J.
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Sep 1, 2023 | 
breathe.ersjournals.com | Rachel Daly |Lynn Elsey |Helen Hope |Siobhan Ludlow
IntroductionRespiratory symptoms such as dyspnoea, chest and throat tightness, cough, and noisy breathing are nonspecific, and clinical assessment and testing are required to make a diagnosis. Many patients have persistent symptoms either in the absence of an obvious cause or when the most obvious cause has been adequately treated. We use the term “complex breathlessness” to describe this presentation, as also defined in the ERS Monograph in 2022 [1].
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Aug 31, 2023 | 
nature.com | Yi-Hsuan Chiang |Pierpaolo Ginefra |Helen Hope |Charles Bataclan |Yi-Ru Yu |Frédérica Schyrr | +1 more
AbstractAging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During aging, hematopoietic stem cells (HSCs) lose their blood reconstitution capability and commit preferentially toward the myeloid lineage (myeloid bias)1,2. These processes are accompanied by an aberrant accumulation of mitochondria in HSCs3.
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Aug 27, 2023 | 
wellandgood.com | Helen Hope
If pickleball feels inescapable right now, there's a good reason for that: It’s officially America’s fastest-growing sport. With pickleball currently on track to have about , it’s clear that plenty of people think that this mashup of tennis, ping pong, and badminton is really freaking fun. Pickleball in particular is beneficial for the building and maintaining the strength of your bones, and protecting them from fractures. Here are four major reasons why. 1.
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Aug 26, 2023 | 
wellandgood.com | Helen Hope
With pickleball’s recent stratospheric rise in popularity has come a huge uptick in pickleball-related injuries. In 2023 alone, pickleball injuries are anticipated to cost Americans $377 million in healthcare bills—anywhere between 5 percent and 10 percent of overall “unexpected” healthcare costs for this year. Completing a proper pickleball warm-up before any game is one of the best ways to avoid becoming part of these statistics.
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Aug 2, 2023 | 
wellandgood.com | Helen Hope
As host of her own travel show on PBS, Samantha Brown spends a lot of time on her feet. So when her dogs are barking, she relies on a trick she learned years ago while working grueling double shifts as a restaurant server in New York City: Whenever she had a short break, she’d switch into flip flops to give her toes some fresh air and space to spread out. Then, Brown would sprinkle on powder to absorb moisture and odor.
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Jun 16, 2023 | 
wellandgood.com | Helen Hope
