Massimo Andreatta

1 month ago | nature.com | Helen Hope |Pierpaolo Ginefra |Massimo Andreatta |Christine Pich-Bavastro |Jesús Corria Osorio |François Kuonen | +4 more

AbstractChimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show that CAR-T cells generated from aged female mice present a mitochondrial dysfunction derived from nicotinamide adenine dinucleotide (NAD) depletion that leads to poor stem-like properties and limited functionality in vivo.

Sep 14, 2023 | nature.com | Massimo Andreatta |Cristina Lopez-Rodriguez |George Coukos |Melita B. Irving |Santiago J Carmona |Werner Held | +2 more

AbstractPersistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion are thought to be common in infection and cancer, despite obvious differences in their microenvironments.