Pierpaolo Ginefra

1 month ago | nature.com | Helen Hope |Pierpaolo Ginefra |Massimo Andreatta |Christine Pich-Bavastro |Jesús Corria Osorio |François Kuonen | +4 more

AbstractChimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show that CAR-T cells generated from aged female mice present a mitochondrial dysfunction derived from nicotinamide adenine dinucleotide (NAD) depletion that leads to poor stem-like properties and limited functionality in vivo.

Aug 31, 2023 | nature.com | Yi-Hsuan Chiang |Pierpaolo Ginefra |Helen Hope |Charles Bataclan |Yi-Ru Yu |Frédérica Schyrr | +1 more

AbstractAging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During aging, hematopoietic stem cells (HSCs) lose their blood reconstitution capability and commit preferentially toward the myeloid lineage (myeloid bias)1,2. These processes are accompanied by an aberrant accumulation of mitochondria in HSCs3.