Pierpaolo Ginefra

Aug 31, 2023 | nature.com | Yi-Hsuan Chiang |Pierpaolo Ginefra |Helen Hope |Charles Bataclan |Yi-Ru Yu |Frédérica Schyrr | +1 more

AbstractAging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During aging, hematopoietic stem cells (HSCs) lose their blood reconstitution capability and commit preferentially toward the myeloid lineage (myeloid bias)1,2. These processes are accompanied by an aberrant accumulation of mitochondria in HSCs3.