Heming Wang

Sep 3, 2024 | medrxiv.org | Raymond Noordam |Wenyi Wang |Pavithra Nagarajan |Heming Wang

HJG has received travel grants and speakers honoraria from Neuraxpharm, Servier, Indorsia and Janssen Cilag. LMR is a consultant for the TOPMed Administrative Coordinating Center (through Westat). TDS is co-founder and shareholder of ZOE Ltd. All other co-authors declare to have no conflicts of interest. This project was largely supported by two grants from the U.S. National Heart, Lung, and Blood Institute (NHLBI), the National Institutes of Health, R01HL118305 and R01HL156991.

Apr 5, 2024 | digitalcommons.library.tmc.edu | Brian E. Cade |Jiwon Lee |Tamar Sofer |Heming Wang

BACKGROUND: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. METHODS: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals.

Dec 4, 2023 | biorxiv.org | Junhua Liu |Xiaofang He |Qingyao Zhu |Heming Wang

AbstractChimeric antigen receptor (CAR) T-cell therapies have shown remarkable results in patients with hematological malignancies. However, their success in treating solid tumors has been limited. As an alternative candidate for the CAR approach, CAR-macrophages (CAR-M) have demonstrated activation and phagocytosis directed by tumor antigens, showing promise in the treatment of solid tumors.