Hong Zhou Chen

Oct 8, 2024 | nature.com | Yuchen chen |Robert Petersen |Xiang Cheng |Yanxun V. Yu |Ling Zheng |Hong Zhou Chen

AbstractParkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms droplets via liquid-liquid phase separation (LLPS), followed by liquid-solid phase separation (LSPS) to form amyloids, how this process is physiologically-regulated remains unclear. β-synuclein colocalizes with α-synuclein in presynaptic terminals.

Jul 22, 2024 | onlinelibrary.wiley.com | Fang Wang |qiang li |Hong Zhou Chen

REFERENCES , & (2019). Automation and new tasks: How technology displaces and reinstates labor. Journal of Economic Perspectives, 33(2), 3–30. https://doi.org/10.1257/jep.33.2.3 , , & (2019). Exploring the impact of artificial intelligence: Prediction versus judgment. Information Economics and Policy, 47, 1–6. https://doi.org/10.1016/j.infoecopol.2019.05.001 , , & (2003). Are selling, general, and administrative costs “sticky”? Journal of Accounting Research, 41(1), 47–63.

Dec 7, 2023 | onlinelibrary.wiley.com | Zhiqiang Wang |Chemometrics College |Linlin Wang |Hong Zhou Chen

Conflict of interest The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

Aug 19, 2023 | nature.com | Hong Zhou Chen

AbstractAcoustic coupling through hairs remains a challenge to performing transcranial-focused ultrasound procedures. Here, we demonstrated that this challenge could be addressed by using oil as the coupling medium, leveraging oil's high affinity to hairs due to their inherent hydrophobicity.

Jul 17, 2023 | nature.com | Yuchen chen |Robert Petersen |Hong Zhou Chen |Kun Huang

AbstractAcute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1 (KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for various renal diseases. However, the exact role and underlying mechanism of KIM1 in the progression of AKI remain elusive. Herein, we report that renal tubular specific knockout of Kim1 attenuates cisplatin- or ischemia/reperfusion-induced AKI in male mice.