Yanxun V. Yu

Oct 8, 2024 | nature.com | Yuchen chen |Robert Petersen |Xiang Cheng |Yanxun V. Yu |Ling Zheng |Hong Zhou Chen

AbstractParkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms droplets via liquid-liquid phase separation (LLPS), followed by liquid-solid phase separation (LSPS) to form amyloids, how this process is physiologically-regulated remains unclear. β-synuclein colocalizes with α-synuclein in presynaptic terminals.