Ling Zheng

1 month ago | science.org | Donghee Lee |Chana F. Kranzler |Daniel Francois |Yushuo Xiao |Zhijian Tong |Chen Wang | +17 more

AbstractAcute kidney injury (AKI) has high incidence and mortality rates. Present treatments are mostly symptomatic and cause side effects due to systemic distribution; thus, targeted kidney drug delivery is desired. Transmembrane kidney injury molecule-1 (KIM1) is expressed at low levels in normal kidneys but markedly up-regulated following injury, making it an ideal marker/target for injured kidneys.

Nov 26, 2024 | nature.com | Jing Yang |Robert Petersen |Ling Zheng |Yu ZHANG

AbstractUpon genotoxic stresses, cells employ various DNA damage responses (DDRs), including DNA damage repair or apoptosis, to safeguard genome integrity. However, the determinants among different DDRs choices are largely unknown. Here, we report angiopoietin-like protein 8 (ANGPTL8), a secreted regulator of lipid metabolism, localizes to the nucleus and acts as a dynamic switch that directs DDRs towards apoptosis rather than DNA repair after genotoxin exposure.

Oct 8, 2024 | nature.com | Yuchen chen |Robert Petersen |Xiang Cheng |Yanxun V. Yu |Ling Zheng |Hong Zhou Chen

AbstractParkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms droplets via liquid-liquid phase separation (LLPS), followed by liquid-solid phase separation (LSPS) to form amyloids, how this process is physiologically-regulated remains unclear. β-synuclein colocalizes with α-synuclein in presynaptic terminals.

Dec 15, 2023 | mdpi.com | Di Zeng |Ling Zheng |Yinong Li |Jie Zeng

1. IntroductionHumanlike driving, which refers to making driving decisions according to the driver’s preferences, is significant for automated vehicles (AVs). This is because driving behaviors without considering human driver characteristics are likely to not only cause physiological and psychological discomfort to the driver but also affect the cognition, operation, and motion state of other traffic participants, thus endangering traffic safety [1].