Hongwei Zhang

2 months ago | arxiv.org | Hongwei Zhang |Shimin Wang |Wei Xiao |Martin Guay

Nov 14, 2024 | pericles.pericles-prod.literatumonline.com | Hongwei Zhang |Linfu Chen |Soft Materials |Qian Chen

Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adhm202402272-sup-0001-SuppMat.docx2.4 MB Supporting Information References 1, , Nat. Med. 2019, 25, 1030. 2, , , , , , , , , , , , , , , Nat. Commun. 2023, 14, 1606. 3, , , , , , , , , , Semin. Cancer Biol. 2022, 86, 931. 4, , , , , Nat. Rev. Clin. Oncol. 2021, 18, 558. 5, , , , , Adv. Sci. 2024, 11, 2403156. 6, , , , , , , , , , , Science 2023, 380, 203.

Nov 8, 2024 | nature.com | Xiao Qian |Yuduo Guo |Lixin Ma |Haoran Wang |Hongwei Zhang |Shenglun Li | +10 more

Malignant glioma is a highly fatal central nervous system malignancy with high recurrence rates. Oncolytic viruses offer potential treatment but need improvement in efficacy and safety. Here we describe a phase I, dose-escalating, single arm trial (ChiCTR2000032402) to study the safety of Ad-TD-nsIL12, an oncolytic adenovirus expressing non-secreting interleukin-12, in patients with recurrent high-grade glioma that connects with the ventricular system. Eight patients received intratumoral treatment via stereotaxis or an Ommaya reservoir, with doses ranging from 5 × 109 to 5 × 1010vp. The primary end point was to determine the maximal tolerated dose. Secondary endpoints included toxicity and anti-tumour ability. Minimal adverse events were observed at doses of 5 × 109 and 1 × 1010vp. Grade 3 seizure was observed in two patients from Cohort 3 (5 × 1010vp). Therefore, the maximum tolerated dose was determined to be 1 × 1010vp. Four patients developed hydrocephalus during follow-up. Among them, symptoms in two patients were relieved after placement of a ventriculo-peritoneal shunt, and the other two only showed ventriculomegaly on MRI scan without neurological deterioration. Complete response (according to Response Assessment in Neuro-Oncology Criteria) in one patient, a partial response in one patient and post-treatment infiltrations of CD4+ and CD8 + T cells into the tumour were documented during this trial. In conclusion, Ad-TD-nsIL12 has demonstrated safety and preliminary efficacy in patients with recurrent high-grade glioma. Oncolytic viruses have been tested in patients with malignant glioma, however clinical efficacy remains limited. Here the authors report the results of a phase I trial of Ad-TD-nsIL12, an oncolytic adenovirus expressing a mutant (non-secreting) form of IL12, in patients with high-grade glioma.

Oct 28, 2024 | onlinelibrary.wiley.com | Weifu Li |Hongwei Zhang |Lin Li |Wanchao Zhu

INTRODUCTION Crop breeding plays an important role in achieving increased grain production and economic development (Senapati et al., 2022). However, observations spanning approximately 50 years revealed that yields from 24% to 39% of all growing areas have not increased for maize (Zea mays), rice (Oryza sativa), wheat (Triticum aestivum), and soybean (Glycine max) (Ray et al., 2012).

Oct 17, 2024 | mdpi.com | Hongwei Zhang |Qingyun Du |Shuai Zhang |Renfei Yang

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