Huaizhi Qu

Jan 14, 2025 | biorxiv.org | Huaizhi Qu |Xiao Wang |Yuanyuan Zhang |Sheng Wang

AbstractCryogenic electron microscopy (cryo-EM) has become a widely used technique for determining the 3D structures of proteins. However, cryo-EM datasets often exhibit heterogeneity, with protein particle images from multiple conformations or compositional states. Here we propose CryoNeRF, a novel neural radiance fields (NeRF)-based cryo-EM reconstruction framework operating directly in Euclidean 3D space.