Xiao Wang

1 week ago | tandfonline.com | Zhou Chen |Xiao Wang |Xinan Zhang |Ming Lin

ABSTRACTLarge Language Models (LLMs) have demonstrated a remarkable capacity to efficiently learn, comprehend, and process extensive datasets and academic literature, leading to their widespread application across a variety of disciplines. However, the adoption of LLMs in geoscience remains constrained by several inherent limitations, including a lack of geoscience knowledge, difficulties in updating information, insufficient autonomy, high operational costs, and low efficiency.

3 weeks ago | nature.com | Shengsong Xu |Xiao Wang |Jinyi Xu |Xingyu Lei |MengYi Wang |Xiao Yang | +3 more

To investigate the causal relationship between depression, anxiety, and myopia. The multivariable Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies (GWAS) was employed. The anxiety and depression, were used as exposures, and myopia was used as the outcome. Genetic variants associated with depression were derived using GWAS summary statistics from the FinnGen consortium database. Genetic variants associated with anxiety were derived from the Psychiatric Genomics consortium. The inverse-variance-weighted method was the main applied analytic tool and was complemented with comprehensive sensitivity analyses. A total of 21, 10 SNPs were selected as instrumental variables for depression and anxiety, respectively. Based on the IVW analysis, both depression (OR = 1.010, 95% CI = 1.002–1.018, P = 0.016) and anxiety (OR = 1.083, 95%CI = 1.022–1.149, P = 0.008) increased the risk of myopia. After adjusting in the multivariable MR, the IVW and Egger methods indicated that depression (OR = 1.004, 95%CI = 1.000–1.008, P = 0.030) or anxiety (OR = 1.004, 95%CI = 1.001–1.008, P = 0.026) was still associated with elevated risks of myopia. The current study identified a causal relationship between anxiety, depression, and an increased risk of myopia. These observations suggest that when developing strategies to control myopia, it is also important to focus on the mental health of children. Further detailed research is needed to fully understand this issue.

2 months ago | arxiv.org | Xiao Wang |Bo Jiang |Lin Zhu |Guoqi Li

Work on one of the world's most important websites and make an impact on open science.

2 months ago | onlinelibrary.wiley.com | Xiao Wang |Han Wei |Ning Zhang |Shigui Li

CONFLICT OF INTEREST The authors declare no conflicts of interest. Supporting Information Filename Description tpj70106-sup-0001-DataS1.docxWord 2007 document , 3.4 MB Figure S1. Genetic transformation of potato StNF-YA8 gene and identification of transgenic plants. Figure S2. Phenotypic and tuber yield analyses of above-ground parts of transgenic strains. Figure S3. GA and ABA gene expression analysis and protein interaction analysis. Table S1. Primers for PCR amplification. Table S2.

Jan 14, 2025 | biorxiv.org | Huaizhi Qu |Xiao Wang |Yuanyuan Zhang |Sheng Wang

AbstractCryogenic electron microscopy (cryo-EM) has become a widely used technique for determining the 3D structures of proteins. However, cryo-EM datasets often exhibit heterogeneity, with protein particle images from multiple conformations or compositional states. Here we propose CryoNeRF, a novel neural radiance fields (NeRF)-based cryo-EM reconstruction framework operating directly in Euclidean 3D space.