Yuanyuan Zhang
Articles
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Jan 14, 2025 |
biorxiv.org | Huaizhi Qu |Xiao Wang |Yuanyuan Zhang |Sheng Wang
AbstractCryogenic electron microscopy (cryo-EM) has become a widely used technique for determining the 3D structures of proteins. However, cryo-EM datasets often exhibit heterogeneity, with protein particle images from multiple conformations or compositional states. Here we propose CryoNeRF, a novel neural radiance fields (NeRF)-based cryo-EM reconstruction framework operating directly in Euclidean 3D space.
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Oct 2, 2024 |
nature.com | Xinchen Lv |Yuanyuan Zhang |Jianhua Luo |Liang Tao
AbstractClostridioides difficile toxin B (TcdB) is the key virulence factor accounting for C. difficile infection-associated symptoms. Effectively neutralizing different TcdB variants with a universal solution poses a significant challenge. Here we present the de novo design and characterization of pan-specific mini-protein binders against major TcdB subtypes.
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Aug 10, 2024 |
cancernetwork.com | Erika Hamilton |Rinath Jeselsohn |Sara A. Hurvitz |Dejan Juric |Hyo S Han |Melinda L. Telli | +8 more
BackgroundVepdegestrant (ARV-471) is an oral proteolysis-targeting chimeras (PROTAC) estrogen receptor (ER) degrader. In a phase 1/2 study (NCT04072952), vepdegestrant monotherapy had a favorable safety profile and encouraging clinical activity with robust ER degradation. The phase 1b cohort of this study is evaluating vepdegestrant plus the CDK4/6inhibitor palbociclib.
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Jul 12, 2024 |
mdpi.com | Yiping Liu |Jianqiang Zhang |Yuanyuan Zhang |Jiarui Wang
1. IntroductionIn recent years, the concept of unmanned systems has gained significant traction. Notably, unmanned surface vehicles (USVs) have experienced rapid advancement. As crucial elements of unmanned maritime systems, USVs offer advantages such as high-speed intelligence, compact size, maneuverability, and cost-effectiveness compared to traditional surface vessels [1].
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Jun 21, 2024 |
mdpi.com | Yuanyuan Zhang |Long Zhao
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Yuanyuan Zhang SciProfiles Scilit Preprints.org Google Scholar and Long Zhao SciProfiles Scilit Preprints.org Google Scholar * School of Environmental and Safety Engineering, Liaoning Petrochemical University, Fushun 113001, China *Author to whom correspondence should be addressed.
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