Huanwei Wang

Mar 12, 2024 | nature.com | Angli Xue |Zhihong Zhu |Huanwei Wang |Peter M. Visscher |Jian Zeng

AbstractSubstance use behaviours (SUB) including smoking, alcohol consumption, and coffee intake are associated with many health outcomes. However, whether the health effects of SUB are causal remains controversial, especially for alcohol consumption and coffee intake. In this study, we assess 11 commonly used Mendelian Randomization (MR) methods by simulation and apply them to investigate the causal relationship between 7 SUB traits and health outcomes.

Sep 18, 2023 | nature.com | Adrian Campos |Shinichi Namba |Julia Sidorenko |Huanwei Wang |Seunggeun Lee |Yen-Feng Lin | +3 more

AbstractGenome-wide association studies (GWASs) have been mostly conducted in populations of European ancestry, which currently limits the transferability of their findings to other populations. Here, we show, through theory, simulations and applications to real data, that adjustment of GWAS analyses for polygenic scores (PGSs) increases the statistical power for discovery across all ancestries.