Huifang Li

Sep 29, 2023 | nature.com | Huifang Li |Yu Zhao |Xiangrong Song

AbstractAlthough mRNA vaccines are known as potent activators of antigen-specific immune responses against infectious diseases, limited understanding of how they drive the functional commitment of CD8+ T cells in tumor microenvironment (TME) and secondary lymphoid organs hinders their broader application in cancer immunotherapy.

Aug 3, 2023 | nature.com | Huifang Li |Da Jia |Lunzhi Dai |Lu Chen |Chong Chen |Yu Chi Liu

AbstractDetecting and targeting precancerous cells in noncancerous tissues is a major challenge for cancer prevention. Massive stabilization of mutant p53 (mutp53) proteins is a cancer-specific event that could potentially mark precancerous cells, yet in vivo protein-level mutp53 reporters are lacking. Here we developed two transgenic protein-level mutp53 reporters, p53R172H–Akaluc and p53–mCherry, that faithfully mimic the dynamics and function of mutp53 proteins in vivo.