Da Jia

Aug 11, 2024 | nature.com | Junhong Qin |Miaomiao Chen |Dan Liu |Zexian Liu |Weimin Xuan |Lunzhi Dai | +2 more

AbstractLysine β-hydroxybutyrylation (Kbhb) is a post-translational modification induced by the ketogenic diet (KD), a diet showing therapeutic effects on multiple human diseases. Little is known how cellular processes are regulated by Kbhb. Here we show that protein Kbhb is strongly affected by the KD through a multi-omics analysis of mouse livers.

Aug 11, 2024 | flipboard.com | Junhong Qin |Xinhe Huang |Shengsong Gou |Sitao Zhang |Qian Zhang |Hongyu Chen | +14 more

Natural Sciences1 hour agoZookeepers Say They’ve Solved the Mystery of How a Gibbon Got Pregnant by HerselfVICE • 1hFor two years, a zoo in southern Japan had been puzzled by a mystery: How did Momo, a gibbon kept alone in her cage, get pregnant? The 12-year-old white-handed gibbon lived by herself and was never joined by a companion.

May 21, 2024 | nature.com | Shuai Tan |Colin Bergstrom |Gonçalo Vale |Jeffrey McDonald |Andrew Schmidt |Nguyen Vo | +4 more

AbstractNutrient handling is an essential function of the gastrointestinal tract. Hormonal responses of small intestinal enteroendocrine cells (EECs) have been extensively studied but much less is known about the role of colonic EECs in metabolic regulation. To address this core question, we investigated a mouse model deficient in colonic EECs. Here we show that colonic EEC deficiency leads to hyperphagia and obesity.

Nov 9, 2023 | nature.com | Da Jia

AbstractProper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear or cytoplasmic compartments.

Aug 3, 2023 | nature.com | Huifang Li |Da Jia |Lunzhi Dai |Lu Chen |Chong Chen |Yu Chi Liu

AbstractDetecting and targeting precancerous cells in noncancerous tissues is a major challenge for cancer prevention. Massive stabilization of mutant p53 (mutp53) proteins is a cancer-specific event that could potentially mark precancerous cells, yet in vivo protein-level mutp53 reporters are lacking. Here we developed two transgenic protein-level mutp53 reporters, p53R172H–Akaluc and p53–mCherry, that faithfully mimic the dynamics and function of mutp53 proteins in vivo.