Huihui Fan

3 weeks ago | nature.com | Hind Rafei |Rafet Basar |Sunil P Acharya |Vakul Mohanty |Ranjan Upadhyay |Merve Dede | +12 more

AbstractChimeric antigen receptor (CAR) natural killer (NK) cell immunotherapy offers a promising approach against cancer1,2,3. However, the molecular mechanisms that regulate CAR-NK cell activity remain unclear. Here we identify the transcription factor cyclic AMP response element modulator (CREM) as a crucial regulator of NK cell function.

Jul 21, 2023 | nature.com | Huihui Fan |Dapeng Hao |Fatima Zahra Jelloul |Ken Chen |Zhongming Zhao |Kunal Rai | +3 more

Human subjects and treatment regimenBone marrows from eight adult (>=18 years of age) patients on NCT02397720 protocol were included in this study. All patients had histologically proved relapsed or refractory acute myeloid leukemia. Timepoint A was collected at the time of proven relapse or primary refractoriness.