Zhongming Zhao

Aug 5, 2024 | digitalcommons.library.tmc.edu | Mingqiang Wang |Wankun Deng |David Samuels |Zhongming Zhao

AbstractGenetic variation in the mitochondrial genome is linked to important biological functions and various human diseases. Recent progress in single-cell genomics has established single-cell RNA sequencing (scRNAseq) as a popular and powerful technique to profile transcriptomics at the cellular level. While most studies focus on deciphering gene expression, polymorphisms including mitochondrial variants can also be readily inferred from scRNAseq.

Aug 1, 2024 | nature.com | Ashutosh Tripathi |Zhongming Zhao

AbstractInflammation and synapse loss have been associated with deficits in social behavior and are involved in pathophysiology of many neuropsychiatric disorders. Synapse loss, characterized by reduction in dendritic spines can significantly disrupt synaptic connectivity and neural circuitry underlying social behavior. Chronic stress is known to induce loss of spines and dendrites in the prefrontal cortex (PFC), a brain region implicated in social behavior.

Jul 21, 2023 | nature.com | Huihui Fan |Dapeng Hao |Fatima Zahra Jelloul |Ken Chen |Zhongming Zhao |Kunal Rai | +3 more

Human subjects and treatment regimenBone marrows from eight adult (>=18 years of age) patients on NCT02397720 protocol were included in this study. All patients had histologically proved relapsed or refractory acute myeloid leukemia. Timepoint A was collected at the time of proven relapse or primary refractoriness.