Hyuk-Soo Seo

Feb 23, 2023 | nature.com | Hyuk-Soo Seo |Jared Johnson |Jianwei Che |Lewis C. Cantley |Benjamin Cravatt |Sirano Dhe-Paganon | +2 more

AbstractCreatine kinases (CKs) provide local ATP production in periods of elevated energetic demand, such as during rapid anabolism and growth. Thus, creatine energetics has emerged as a major metabolic liability in many rapidly proliferating cancers. Whether CKs can be targeted therapeutically is unknown because no potent or selective CK inhibitors have been developed.

Feb 14, 2023 | nature.com | Etsuro Nanishi |Hyuk-Soo Seo |Kijun Song |Andrew Xu |Soumik Barman |Blake M Hauser | +8 more

AbstractDevelopment of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to identify a combination that elicits antibodies and protection in young and aged mice. While demonstrating superior immunogenicity to soluble receptor-binding domain (RBD), RBD displayed as a protein nanoparticle (RBD-NP) generated limited antibody responses.