Sirano Dhe-Paganon

Feb 23, 2023 | nature.com | Hyuk-Soo Seo |Jared Johnson |Jianwei Che |Lewis C. Cantley |Benjamin Cravatt |Sirano Dhe-Paganon | +2 more

AbstractCreatine kinases (CKs) provide local ATP production in periods of elevated energetic demand, such as during rapid anabolism and growth. Thus, creatine energetics has emerged as a major metabolic liability in many rapidly proliferating cancers. Whether CKs can be targeted therapeutically is unknown because no potent or selective CK inhibitors have been developed.