Il-Kyu Kim

Feb 20, 2024 | nature.com | Il-Kyu Kim |Jeffrey Lin |Stacy Thomas |Takeshi Katsuda |John W. Tobias |Robert H Vonderheide

AbstractAcquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses, we find that resistance is reproducibly associated with an epithelial-to-mesenchymal transition (EMT), with EMT-transcription factors ZEB1 and SNAIL functioning as master genetic and epigenetic regulators of this effect.