Takeshi Katsuda

Jul 26, 2024 | onlinelibrary.wiley.com | Takeshi Katsuda |Jonathan Sussman |Kenneth S. Zaret |Ben Z. Stanger

INTRODUCTION Pioneer transcription factors (TFs) play a crucial role in cell fate decisions during embryonic development and cellular reprogramming via their unique ability to enact persistent epigenomic changes.[1, 2] The name “pioneer factor” derives from an ability to facilitate chromatin opening; whereas most TFs can bind to regions of chromatin that are already accessible, pioneer factors have an increased ability to bind to DNA regions that are embedded in nucleosomes (“closed...

Feb 20, 2024 | nature.com | Il-Kyu Kim |Jeffrey Lin |Stacy Thomas |Takeshi Katsuda |John W. Tobias |Robert H Vonderheide

AbstractAcquired resistance to immunotherapy remains a critical yet incompletely understood biological mechanism. Here, using a mouse model of pancreatic ductal adenocarcinoma (PDAC) to study tumor relapse following immunotherapy-induced responses, we find that resistance is reproducibly associated with an epithelial-to-mesenchymal transition (EMT), with EMT-transcription factors ZEB1 and SNAIL functioning as master genetic and epigenetic regulators of this effect.

Feb 14, 2023 | biorxiv.org | Jonathan Sussman |Kenji Ito |Takeshi Katsuda |Andrew Katznelson

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