Ilan E. Chemmama

Jan 12, 2024 | nature.com | Ruchika Bajaj |Ilan E. Chemmama |Meghna Gupta |Andrej Sali |Yifan Cheng |Charles S. Craik

AbstractMultidrug resistance protein 4 (MRP4) is a broadly expressed ATP-binding cassette transporter that is unique among the MRP subfamily for transporting prostanoids, a group of signaling molecules derived from unsaturated fatty acids. To better understand the basis of the substrate selectivity of MRP4, we used cryogenic-electron microscopy to determine six structures of nanodisc-reconstituted MRP4 at various stages throughout its transport cycle.