Meghna Gupta

2 months ago | science.org | Rich Pang |Megan McSweeney |Lu Chen |Meghna Gupta

AbstractNeuromyelitis optica (NMO) is an autoimmune disease of the central nervous system where pathogenic autoantibodies target the water channel aquaporin-4 on human astrocytes causing neurological impairment. Autoantibody binding leads to complement-dependent and complement-independent cytotoxicity, ultimately resulting in astrocyte death, demyelination, and neuronal loss. Aquaporin-4 assembles in astrocyte plasma membranes as symmetric tetramers or as arrays of tetramers.

Jan 12, 2024 | nature.com | Ruchika Bajaj |Ilan E. Chemmama |Meghna Gupta |Andrej Sali |Yifan Cheng |Charles S. Craik

AbstractMultidrug resistance protein 4 (MRP4) is a broadly expressed ATP-binding cassette transporter that is unique among the MRP subfamily for transporting prostanoids, a group of signaling molecules derived from unsaturated fatty acids. To better understand the basis of the substrate selectivity of MRP4, we used cryogenic-electron microscopy to determine six structures of nanodisc-reconstituted MRP4 at various stages throughout its transport cycle.

Jun 2, 2023 | globalspaonline.com | Meghna Gupta

Beauty Expert-Approved Skincare Tips for the Perfect Summer Glow By Dr. Meghna Gupta Dr. Meghna Gupta, Dermatologist and Founder of Delhi Skin Centre, shows you how to summer-proof your skin The various environmental changes that arrive with each season of the year might impact your skin in one way or another. As a result, you must modify your skincare regimen every season if you want to provide the best possible care.