Itaru Kushima

Dec 4, 2024 | biologicalpsychiatryjournal.com | Itaru Kushima

ReviewArticles in PressOpen access 1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan 2Medical Genomics Center, Nagoya University Hospital, Nagoya, Japan 3Public Health Informatics Unit, Nagoya University Graduate School of Medicine, Nagoya, Japan 4Pathophysiology of Mental Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan 5Institute for Glyco-core Research (iGCORE), Nagoya University, Nagoya, Japan Publication History: Received April...

Oct 13, 2024 | nature.com | Shinichi Namba |Masato Akiyama |Haruka Hamanoue |Itaru Kushima |Koichi Matsuda |Masahiro Nakatochi | +4 more

Private enterprises offer preimplantation genetic testing with polygenic scores to select embryos with ‘desirable’ potential. In silico simulations using biobank resources show that the selected embryo would rely substantially on the choice of polygenic score method and randomness in score construction, which raises ethical concerns.