Masahiro Nakatochi

Nov 5, 2024 | nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more

Correction to: Nature Genetics https://doi.org/10.1038/s41588-024-01921-5. Published online 15 October 2024. In the version of the article originally published, there were errors in the consortium lists at the end of the paper. Maureen Rischmueller, Hyon K. Choi, Masahiro Nakatochi, Jeff N. Miner, Daniel H. Solomon, Kathleen M. Giacomini and Deanna J. Brackman were erroneously listed as members of the Japan Gout Genomics Consortium.

Oct 15, 2024 | nature.com | Tanya J. Major |Riku Takei |Yuya Shirai |Wei Qing Wang |Murray Cadzow |Amanda Phipps-Green | +35 more

AbstractGout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood inflammatory component of gout from a genome-wide association study (GWAS) of 2.6 million people, including 120,295 people with prevalent gout. We detected 377 loci and 410 genetically independent signals (149 previously unreported loci in urate and gout).

Oct 13, 2024 | nature.com | Shinichi Namba |Masato Akiyama |Haruka Hamanoue |Itaru Kushima |Koichi Matsuda |Masahiro Nakatochi | +4 more

Private enterprises offer preimplantation genetic testing with polygenic scores to select embryos with ‘desirable’ potential. In silico simulations using biobank resources show that the selected embryo would rely substantially on the choice of polygenic score method and randomness in score construction, which raises ethical concerns.

Jan 26, 2024 | science.org | Yuriko N. Koyanagi |Clémentine Eva Philibert |Seunghyun Moon |Masahiro Nakatochi

Research ArticleEPIDEMIOLOGYYuriko N.

Jan 26, 2024 | sciencemag.org | Yuriko N. Koyanagi |Clémentine Eva Philibert |Seunghyun Moon |Masahiro Nakatochi

Published In Science AdvancesVolume 10 | Issue 4January 2024Article versionsSubmission historyReceived: 8 August 2022Accepted: 26 December 2023PermissionsSee the Reprints and Permissions page for information about permissions for this article. AcknowledgmentsWe are grateful to the participants and all staff members in this study. We thank J. Dupuis of McGill University Faculty of Medicine and Health Sciences and A. K.