J. Javier Meana

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G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits - Nature Communications

May 29, 2024 | nature.com | Elk Kossatz |Rebeca Diez-Alarcia |Carla Ramon-Duaso |Suwipa Saen-Oon |Peter Kolb |Michel Bouvier | +2 more

AbstractG protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific therapeutic applications. This is the case for the serotonin 2 A receptor (5-HT2AR), a prominent target for the treatment of schizophrenia.
El 'boom' de las drogas psicodélicas - Ethic

Sep 15, 2023 | ethic.es | Efecto Naím |Iñaki Domínguez |Luis F Callado |J. Javier Meana

Las microdosis han sacado el consumo de la psilocibina, el LSD y otras sustancias de la contracultura. Hoy, sus consumidores ya no solo visten túnicas o buscan descubrir las «realidades alternativas», también esperan potenciar la creatividad o activar beneficios terapéuticos. Bienvenidos al nuevo (y viejo) mundo de la psicodelia. ¿QUIERES COLABORAR CON ETHIC?
Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes - Nature Communications

Aug 3, 2023 | nature.com | Sai Ma |J. Javier Meana

AbstractThe genome-wide DNA methylation profile, or DNA methylome, is a critical component of the overall epigenomic landscape that modulates gene activities and cell fate. Single-cell DNA methylomic studies offer unprecedented resolution for detecting and profiling cell subsets based on methylomic features. However, existing single-cell methylomic technologies are based on use of tubes or well plates and these platforms are not easily scalable for handling a large number of single cells.
Los cuatro (¿o cinco?) elementos

Mar 8, 2023 | ethic.es | David Lorenzo Cardiel |Luis F Callado |J. Javier Meana |Jorge Ratia

En Occidente, la cultura griega nos ha legado cuatro elementos: tierra, agua, aire y fuego. Sin embargo, en India y en China son, habitualmente, cinco. ¿Cómo ha influido esta diferencia en el devenir de las civilizaciones? ¿QUIERES COLABORAR CON ETHIC?