Jacob Bergstedt

Jun 16, 2024 | nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more

AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.

Jun 12, 2024 | nature.com | Joeri J. Meijsen |Kejia Hu |Morten Krebs |Georgios Athanasiadis |Sarah Washbrook |Richard Zetterberg | +14 more

AbstractMental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders.

May 21, 2024 | medrxiv.org | Joëlle A Pasman |Jacob Bergstedt |Arvid Harder |Ying Xiong

PFS is consultant and shareholder at Neumora Therapeutics. No other authors report potential conflicts of interest. This work was supported by the US National Institutes of Mental Health (R01MH123724), the European Unions Horizon 2020 Research and Innovation Programme (CoMorMent project; Grant #847776) and the European Research Council (grant agreement ID 101042183). The OSMR analyses have been conducted using the UK Biobank Resource under Application Number 22224.

Mar 6, 2024 | jamanetwork.com | Hilda Björk Daníelsdóttir |Jacob Bergstedt |Unnur Valdimarsdóttir

Key PointsQuestion  Are adverse childhood experiences (ACEs) associated with poor mental health in adulthood after adjustment for familial confounding due to shared genetic and environmental factors? Findings  In this cohort study using twin data, there were associations between ACEs and adult mental health outcomes in dizygotic and monozygotic twin pairs, while odds ratios were attenuated compared with the full cohort.