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Sep 26, 2024 | 
nature.com | Mary Barker |Kadri Koiv |Ingibjörg Magnúsdóttir |Hannah Milbourn |Bin Wang |Gillian Murphy | +15 more
AbstractIndividuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results.
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Jun 16, 2024 | 
nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more
AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.
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Jun 12, 2024 | 
nature.com | Joeri J. Meijsen |Kejia Hu |Morten Krebs |Georgios Athanasiadis |Sarah Washbrook |Richard Zetterberg | +14 more
AbstractMental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders.
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May 15, 2024 | 
nature.com | Fang Fang |Unnur Valdimarsdóttir |Qian Li
AbstractPre-existing psychiatric disorders were linked to an increased susceptibility to COVID-19 during the initial outbreak of the pandemic, while evidence during Omicron prevalence is lacking. Leveraging data from two prospective cohorts in China, we identified incident Omicron infections between January 2023 and April 2023.
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Apr 11, 2024 | 00075-6/fulltext&sz=64)
thelancet.com | Svava Jónsdóttir |Edda Bjork Thordardottir |Unnur Valdimarsdóttir
Research in contextEvidence before this studyWe conducted a literature search on workplace sexual harassment and violence and health outcomes, using the following databases: Web of Science, PubMed, Sage Journals, Science Direct, and Google Scholar.
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Mar 6, 2024 | 
jamanetwork.com | Hilda Björk Daníelsdóttir |Jacob Bergstedt |Unnur Valdimarsdóttir
Key PointsQuestion
Are adverse childhood experiences (ACEs) associated with poor mental health in adulthood after adjustment for familial confounding due to shared genetic and environmental factors? Findings
In this cohort study using twin data, there were associations between ACEs and adult mental health outcomes in dizygotic and monozygotic twin pairs, while odds ratios were attenuated compared with the full cohort.
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Feb 7, 2024 | 
nature.com | Xin Han |Qing Shen |Can Hou |Weimin Ye |Fang Fang |Unnur Valdimarsdóttir
AbstractAnxiety/stress-related disorders have been associated with multiple diseases, whereas a comprehensive assessment of the structure and interplay of subsequent associated diseases and their genetic underpinnings is lacking.
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Feb 5, 2024 | 
nature.com | Emma Bränn |Yufeng Chen |Huan Song |Elgeta Hysaj |Henrik R. Larsson |Paul Lichtenstein | +1 more
Correction to: Molecular Psychiatry https://doi.org/10.1038/s41380-023-02351-1, published online 09 January 2024In Table 4 of this article, in the column headed No PNDa, n, on the row headed Diabetes mellitus. insulin dependent, the value ‘2.723’ should have read ‘2723’. In Table 4 of this article, in the column headed No PNDa, n, on the row headed Crohn’s disease, the value ‘2,06’ should have read ‘2060’. The original article has been corrected.
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Jan 10, 2024 | 
bmj.com | Emma Bränn |Anna Öberg |Unnur Valdimarsdóttir |Naela Hagatulah
MethodsWe conducted a matched cohort study based on the nationwide population, followed by a sibling comparison to further control for shared familial confounding, by leveraging the nationwide health registers in Sweden.
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Jan 8, 2024 | 
nature.com | Emma Bränn |Yufeng Chen |Huan Song |Henrik R. Larsson |Paul Lichtenstein |Unnur Valdimarsdóttir | +1 more
AbstractAlthough major depression, characterized by a pro-inflammatory profile, genetically overlap with autoimmune disease (AD) and the perinatal period involve immune system adaptations and AD symptom alterations, the bidirectional link between perinatal depression (PND) and AD is largely unexplored. Hence, the objective of this study was to investigate the bidirectional association between PND and AD.
