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1 month ago | 
nature.com | Pravesh Parekh |Sara Stinson |Maria Koromina |Jaroslav Rokicki |Ida E Sønderby |Nadine Staples Parker | +11 more
AbstractMetabolites in plasma form biosignatures of a range of common complex human diseases. Discovering variants with pleiotropic effects across metabolites can reveal underlying biological mechanisms. We therefore performed uni- and multivariate genome-wide association studies (GWAS) on 249 circulating metabolic markers across 328,006 UK Biobank and Estonian Biobank participants.
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Jan 17, 2025 | 
nature.com | Elise Koch |Nadine Staples Parker |Siobhan K. Lock |Oleksandr Frei |Anders M. Dale |Srdjan Djurovic | +1 more
AbstractWhile clozapine is the most effective antipsychotic drug, its use is limited due to hematological adverse effects involving the reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown but likely related to clozapine metabolism. Genome-wide association studies (GWASs) of clozapine metabolism and clozapine-induced agranulocytosis have identified few genetic loci.
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Oct 27, 2024 | 
acamh.onlinelibrary.wiley.com | Nadine Staples Parker |Laurie J. Hannigan |Espen Hagen |Nora R. Bakken
Introduction Mood and anxiety disorders, often collectively referred to as emotional disorders (Bullis, Boettcher, Sauer-Zavala, Farchione, & Barlow, 2019), are common and account for a large global burden of disease (Vos et al., 2020). Despite considerable research efforts, the disease mechanisms remain largely unknown (Bennett & Walkup, 2023).
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Oct 1, 2024 | 
nature.com | Shahram Bahrami |Kaja Nordengen |Olav B. Smeland |Nadine Staples Parker |Pravesh Parekh |Torbjørn Elvsåshagen | +4 more
AbstractThe basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans.
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Sep 24, 2024 | 
medrxiv.org | Nadine Staples Parker |Elise Koch |Alexey Shadrin |Julian Führer
OAA has received speaker fees from Lundbeck, Janssen, Otsuka, and Sunovion and is a consultant to Cortechs.ai. and Precision Health. AMD is Founding Director, holds equity in CorTechs Labs, Inc. (DBA Cortechs.ai), and serves on its Board of Directors and the Scientific Advisory Board. He is an unpaid consultant for Oslo University Hospital. The terms of these arrangements have been reviewed and approved by the University of California, San Diego in accordance with its conflict-of-interest policies.
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Jun 16, 2024 | 
nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more
AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.
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Jun 3, 2024 | 
nature.com | Oleksandr Frei |Guy Hindley |Espen Hagen |Nadine Staples Parker |Olav B. Smeland |Christiaan de Leeuw | +2 more
AbstractWhile genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging.
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Apr 29, 2024 | 01000-x/abstract?rss=yes&sz=64)
biologicalpsychiatryjournal.com | Nadine Staples Parker |Piotr Jaholkowski |Guy Hindley |Elise Koch
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Apr 5, 2024 | 
digitalcommons.library.tmc.edu | Guy Hindley |Alexey Shadrin |Nadine Staples Parker |Weiqiu Cheng
To view the content in your browser, please download Adobe Reader or, alternately, you may Download the file to your hard drive. NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.
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Feb 27, 2024 | 
medrxiv.org | Alexey Shadrin |Guy Hindley |Espen Hagen |Nadine Staples Parker
Srdjan Djurovic has received speaker's Honoria from Lundbeck. Anders M. Dale is a Founder of and holds equity in CorTechs Labs, Inc, and serves on its Scientific Advisory Board. He is also a member of the Scientific Advisory Board of Human Longevity, Inc. (HLI), and the Mohn Medical Imaging and Visualization Centre in Bergen, Norway. He receives funding through a research agreement with General Electric Healthcare (GEHC).
