James J. Crowley

2 months ago | nature.com | Diego L. Rovaris |Sintia I. Belangero |Sheila T. Nagamatsu |Caroline M Nievergelt |Roseann E. Peterson |Laura Sloofman | +28 more

AbstractPsychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations.

Mar 27, 2024 | nature.com | Nora I. Strom |Christie L. Burton |René Pool |James J. Crowley |Jouke-Jan Hottenga |Henrik R. Larsson | +6 more

AbstractWhile 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life.