René Pool

Jul 12, 2024 | biorxiv.org | René Pool |Dirk H.M. Pelt |Natalia Azcona Granada |Anne J.M.R. Geijsen

AbstractThe biological complexity of wellbeing is studied from various perspectives, including genetics and epigenetics. However, there is a knowledge gap concerning other layers, such as metabolomics, which is dynamic and changes throughout life. This study explores the association between metabolites and wellbeing in a sample (N = 4748) drawn from the Netherlands Twin Register.

Apr 16, 2024 | medrxiv.org | Fiona A. Hagenbeek |René Pool |Erik A. Ehli |Meike Bartels

The authors have declared no competing interest. The current work is supported by the Consortium on Individual Development (CID) and the "Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies" project (ACTION). CID is funded through the Gravitation Program of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NWO grant number 024-001-003).

Mar 27, 2024 | nature.com | Nora I. Strom |Christie L. Burton |René Pool |James J. Crowley |Jouke-Jan Hottenga |Henrik R. Larsson | +6 more

AbstractWhile 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life.

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.