Janine F. Felix

Oct 5, 2023 | nature.com | Robin Beaumont |Christopher Flatley |Marc Vaudel |JING CHEN |Gunn-Helen Moen |Line Skotte | +52 more

AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.

Jul 19, 2023 | acamh.onlinelibrary.wiley.com | Mannan Luo |Esther Walton |Alexander Neumann |Janine F. Felix

Statistical analysis Epigenome-wide association study Linear regression was applied to investigate the prospective association between neonatal DNAm and LVV in childhood. In our EWAS analyses, the DNAm β value at each CpG site was specified as the predictor and total LVV as the outcome of interest, adjusted for all relevant covariates as described above. Probes were annotated using the meffil R package (Min et al., 2018), based on genome build hg19.