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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley
In the Perspective “Phylogenies of Methylomes” (14 May 2010, p. 837), the figure incorrectly noted evidence of Dnmt3 in Volvox carteri (green alga). This error was introduced at the production stage; it has now been corrected and does not alter the text or conclusions of the Perspective. Information & AuthorsInformationPublished In ScienceVolume 384 | Issue 670221 June 2024CopyrightCopyright ©, American Association for the Advancement of Science.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Rana Hussein
Editor’s summaryThe protein complex photosystem II brings together a large number of cofactors and pigments within a scaffold that allows for movement of water and protons, which are key to the water oxidation chemistry performed at the oxygen-evolving center during photosynthesis. However, it is often challenging to identify water molecules, especially protons, in x-ray crystal structures. Hussein et al.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Hui Wang
InformationPublished In ScienceVolume 384 | Issue 670221 June 2024CopyrightCopyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Article versionsSubmission historyPublished in print: 21 June 2024PermissionsRequest permissions for this article. AuthorsAffiliationsHui WangState Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou 570228, China.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Wei Li
Editor’s summaryBoth engineered and natural structures can exhibit directional liquid transport that is driven by the specific patterning of the surface. Yang et al. drew inspiration from the Crassula muscosa plant, in which the direction of fluid flow is determined by the shape and orientation of the structured fins, which can vary from stem to stem, and by the surface tension of the fluid.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Rafael Yuste
Daniel Clement Dennett, who merged philosophical thinking with scientific evidence from many fields, died on 19 April at age 82. In the central question of the nature of the mind, Dennett took a neuroscience-anchored position, arguing that consciousness and all higher cognitive abilities could be understood as a direct consequence of the physiology of the brain.
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Jun 20, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla |Jaroslav Zak |Isaraphorn Pratumchai
Editor’s summaryCancer immunotherapy is a type of treatment that mobilizes a patient’s immune system to kill tumor cells. It has been successful in treating certain tumors, but patients frequently have chronic inflammation and immunosuppression, which can limit treatment response.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Matthew Bunn
Matthew Bunn [email protected] Info & AffiliationsScience20 Jun 2024Vol 384, Issue 6702p. 1277Dark clouds loom on the nuclear horizon, with threats from all directions: Russia’s nuclear bombast in its war on Ukraine, China’s construction of hundreds of nuclear missile silos, North Korea’s missile testing, India and Pakistan’s ongoing nuclear competition, and Iran’s push toward nuclear weapons capability.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Yi Cheng
eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Massimo Gadina
PerspectiveCancerJanus kinase (JAK) inhibitors improve antitumor responsesMassimo Gadina [email protected] and John J. O’Shea [email protected] Info & AffiliationsScience20 Jun 2024Vol 384, Issue 6702pp. 1303-1304AbstractThe understanding of the immune system has increased considerably in the past 30 years, leading to the development of better therapies for cancer as well as immune-mediated disorders.
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Jun 20, 2024 | 
science.org | Jaroslav Zak |Divij Mathew |Andrew E. Whiteley |Claire Coupland
AbstractIntercellular communication in the nervous system occurs through the release of neurotransmitters into the synaptic cleft between neurons. In the presynaptic neuron, the proton pumping vesicular- or vacuolar-type ATPase (V-ATPase) powers neurotransmitter loading into synaptic vesicles (SVs), with the V1 complex dissociating from the membrane region of the enzyme before exocytosis. We isolated SVs from rat brain using SidK, a V-ATPase-binding bacterial effector protein.
