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Nov 6, 2024 | 
digitalcommons.library.tmc.edu | Krishnan K Mahadevan |Valerie S LeBleu |Elena Ramirez |Yang Chen
AbstractOncogenic KRASG12D (KRAS∗) is critical for the initiation and maintenance of pancreatic ductal adenocarcinoma (PDAC) and is a known repressor of tumor immunity. Conditional elimination of KRAS∗ in genetic mouse models of PDAC leads to the reactivation of FAS, CD8+ T cell-mediated apoptosis, and complete eradication of tumors. KRAS∗ elimination recruits activated CD4+ and CD8+ T cells and promotes the activation of antigen-presenting cells.
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Nov 6, 2024 | 
digitalcommons.library.tmc.edu | Krishnan K Mahadevan |Kathleen M. McAndrews |Valerie S LeBleu |Sujuan Yang
AbstractThe KRASG12D mutation is present in nearly half of pancreatic adenocarcinomas (PDAC). We investigated the effects of inhibiting the KRASG12D mutant protein with MRTX1133, a non-covalent small molecule inhibitor of KRASG12D, on early and advanced PDAC and its influence on the tumor microenvironment.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla
In the Research Article “Spin-mediated promotion of Co catalysts for ammonia synthesis” (21 March 2024, p.1357), the authors found a typing error in an exponent of a constant in the Excel program used for conversion of the quadrupole mass spectrometry signal to reaction rate. The program was applied to all model systems measured in this research, and all the reaction rates [observed turnover frequency (TOF)] in the article were calculated one order of magnitude too high.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla |L. Bryan Ray |Brent Grocholski
Biophysics Deep-sea membranes use the bendsL. Bryan RayDeep sea organisms such as the comb jelly Beroe cucumis, pictured here, produce phospholipids that aid in adaptation to extreme pressure. PHOTO: SEATOPS/ALAMY STOCK PHOTOOpen in viewerExtreme pressures thousands of feet deep in the ocean are sufficient to compress the conformation of the molecules that form biological membranes. Winnikoff et al. explored how comb jellies have adapted to such pressures.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla |Allison M Dyevoich |Yang Chen
1F. Balkwill, A. Mantovani, Inflammation and cancer: Back to Virchow?Lancet 357, 539–545 (2001). 2I. Gukovsky, N. Li, J. Todoric, A. Gukovskaya, M. Karin, Inflammation, autophagy, and obesity: Common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology 144, 1199–209.e4 (2013). 3M. Perez-Moreno, W. Song, H. A. Pasolli, S. E. Williams, E. Fuchs, Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer. Proc. Natl. Acad. Sci. U.S.A. 105, 15399–15404 (2008). 4A.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla
The Perspective “Multistage maturation optimizes vision” (24 May 2024, p. 848) misrepresented some of the findings of the corresponding paper by Vogelsang et al. [M. Vogelsang et al., Science 384, 907 (2024)] by stating that individuals with delayed vision were poorer at perceiving color images compared with black-and-white images. The text has been altered to accurately describe the findings of the paper, and the figure has also been changed accordingly.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla |Cello Latini Pfeil |Isis Gois
Transgender, travesti, and nonbinary (trans) individuals face considerable challenges in Brazil, which have been magnified by the COVID-19 pandemic (1). As trans scientists, we urge Brazil’s government to enact affirmative action policies to support trans individuals pursuing higher education as students and employees. Before even entering university, Brazil’s trans citizens face substantial risks.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla |Abderrazak El Albani |Arnaud Mazurier
Editor’s summaryTrilobites are probably the best known denizens of the Cambrian Period. Their distinctive fossilized external forms are well recognized from an extensive fossil record spanning the early Cambrian to the Permian extinction. The vast majority of trilobite fossils display only external morphology, however, leaving much unknown about their internal morphology. El Albani et al.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla
Historical antecedents to modern tokens offer insight into money’s future. PHOTO: SMITH ARCHIVE/ALAMY STOCK PHOTOOpen in viewerElectronic vouchers such as food stamps, store credit, gift cards, and airline miles have become commonplace in our increasingly online world, providing issuers greater leverage over recipients and more data than other forms of modern currency. But end users have also found ways to benefit from alternative compensation schemes.
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Jun 27, 2024 | 
science.org | Krishnan K Mahadevan |Dawid Zyla |Hao Zheng |Tao Zhou
Editor’s summaryRelaxor ferroelectrics are a class of materials that have an attractive polarization response to an external electric field. This property is attractive for a wide range of potential applications. These materials have small domains of different electrical polarization that allow efficient polarization switching of the material. Zheng et al. used x-ray coherent nanodiffraction to determine how these nanodomains are organized at the scale of hundreds of nanometers.
