Jasper Lithgow

Oct 2, 2023 | pubs.rsc.org | Mariska de Munnik |Jasper Lithgow |Lennart Brewitz |Kirsten Christensen

αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes† Epoxides are an established class of electrophilic alkylating agents that react with nucleophilic protein residues. We report αβ,α′β′-diepoxyketones (DEKs) as a new type of mechanism-based inhibitors of nucleophilic cysteine enzymes.